Symptoms & Diagnosis

Some Common and Less Common Symptoms of Low Thyroid

Original article by Michael Teplitsky, MD

Author Michael Teplitsky, MD Published July 25, 2026 Read 2 min 392 words

Some of the common and less common symptoms of low thyroid

A human body contains about 30 trillion cells, give or take a trillion. Each cell needs energy in order to do its work. There are organelles (little organs) in each cell. The organells that generate the energy are called mitochondria. They burn sugar, protein and fat to produce energy. Sort of like a furnace that burns coal, gas or oil to produce heat and energy. But in order to work, mitochondria need a thyroid hormone called T3. If they do not get enough T3, they will not burn the fuel, so the energy level will be low. Different cells show this lack of energy differently, which is why there are so many symptoms in a person with low thyroid. Some symptoms are quite common and well-known. Some are less known and are not readily recognized, except by a doctor knowledgeable about low thyroid.

Common hypothyroid symptoms

  • fatigue
  • getting tired easily
  • weight gain
  • feeling colder than others
  • constipation
  • hair loss
  • dry skin
  • depression
  • low body temperature

Less common thyroid symptoms

  • anxiety
  • intolerance to cold
  • hoarseness or voice changes
  • lack of motivation
  • mood changes
  • brain fog
  • accelerated hardening of the arteries
  • decreased libido
  • irregular or heavy menstruation
  • infertility
  • decreased hearing
  • muscle weakness or pain
  • joint pain or stiffness
  • numb and tingling hands
  • restless leg syndrome
  • premature graying of hair in young adults
  • swollen eyelids
  • puffy face
  • swelling of the hands, feet, or legs
  • thick tongue
  • carpal tunnel syndrome
  • chronic fatigue syndrome
  • difficult menopause
  • fibrocystic breasts
  • slowed heart rate
  • decreased or increased sweating
  • decreased appetite

This is not a complete list, there are quite a few more symptoms.

Of course, there are other causes of each of these symptoms, but low thyroid should be considered as a potential cause.

Plus, low thyroid can cause changes in certain laboratory tests.

Hypothyroidism can cause mild anemia, with a decrease in hemoglobin and hematocrit levels.

Creatine Kinase (CK or sometimes called CPK) levels may be elevated, indicating muscle damage or inflammation.

Liver Enzymes such as ALT (alanine transaminase) and AST (aspartate transaminase) can go up.

Prolactin, a hormone produced by the pituitary gland, may be elevated, leading to menstrual irregularities.

Hypothyroidism can affect the level of certain electrolytes, such as sodium and potassium.

  • Michael Tepisky, MD

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FAQ from The Metabolic Journal Editors

These questions are based on this article and related Dr. Teplitsky articles.

What symptoms does Dr. Teplitsky connect with low thyroid?

His articles emphasize fatigue, weight gain, feeling colder than others, constipation, hair loss, depression, brain fog, and a long list of less obvious symptoms.

Why can diagnosis be difficult?

Many symptoms overlap with other conditions, and Dr. Teplitsky argues that a narrow lab interpretation can miss some patients who still need a careful thyroid evaluation.

How can I book an appointment with Dr. Teplitsky?

Call Dr. Teplitsky’s office at 718-769-0997 to book an appointment or ask about availability.

Medical Disclaimer: This content is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare provider before making changes to your health regimen.